Defective factor XII causes hereditary angioedema
REACTOME PATHWAYThe Defective factor XII causes hereditary angioedema pathway (Reactome ID: R-HSA-9657688) involves 2 genes and is affected by 2 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Defective factor XII causes hereditary angioedema
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Gabexate | — | 300 |
| 2 | Bortezomib | — | 300 |
About the Defective factor XII causes hereditary angioedema Pathway
The Defective factor XII causes hereditary angioedema pathway is catalogued in Reactome (ID: R-HSA-9657688) and involves 2 genes. In the BiohacksAI corpus, 2 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include F12, KLKB1.