Masitinib-resistant KIT mutants
REACTOME PATHWAYThe Masitinib-resistant KIT mutants pathway (Reactome ID: R-HSA-9669924) involves 1 genes and is affected by 9 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Masitinib-resistant KIT mutants
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | Avapritinib | — | 246 |
| 4 | Dasatinib | — | 299 |
| 5 | Crizotinib | — | 298 |
| 6 | Imatinib Mesylate | — | 300 |
| 7 | pd98059 | — | 7 |
| 8 | N-pyridazin-3-yl-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzylidene)piperidine-1-carboxamide [Supplementary Concept] | — | 8 |
| 9 | sp600125 | — | 117 |
About the Masitinib-resistant KIT mutants Pathway
The Masitinib-resistant KIT mutants pathway is catalogued in Reactome (ID: R-HSA-9669924) and involves 1 genes. In the BiohacksAI corpus, 9 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KIT.