Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
REACTOME PATHWAYThe Signaling by membrane-tethered fusions of PDGFRA or PDGFRB pathway (Reactome ID: R-HSA-9673768) involves 1 genes and is affected by 10 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | Quercetin | — | 300 |
| 4 | Avapritinib | — | 246 |
| 5 | Crizotinib | — | 298 |
| 6 | Dasatinib | — | 299 |
| 7 | kenpaullone | — | 8 |
| 8 | sp600125 | — | 117 |
| 9 | tyrphostin ag 1295 | — | 1 |
| 10 | Vemurafenib | — | 298 |
About the Signaling by membrane-tethered fusions of PDGFRA or PDGFRB Pathway
The Signaling by membrane-tethered fusions of PDGFRA or PDGFRB pathway is catalogued in Reactome (ID: R-HSA-9673768) and involves 1 genes. In the BiohacksAI corpus, 10 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include KDR.