Formation of the ureteric bud
REACTOME PATHWAYThe Formation of the ureteric bud pathway (Reactome ID: R-HSA-9830674) involves 2 genes and is affected by 12 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Formation of the ureteric bud
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Sorafenib | — | 300 |
| 2 | Axitinib | — | 298 |
| 3 | Dasatinib | — | 299 |
| 4 | Crizotinib | — | 298 |
| 5 | Nortriptyline | — | 295 |
| 6 | Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent | — | 299 |
| 7 | sp600125 | — | 117 |
| 8 | Apigenin 5,7,4'-trihydroxy-flavone, | — | 300 |
| 9 | Methylene Blue | — | 200 |
| 10 | Cefdinir | — | 298 |
| 11 | Fusaric Acid | — | 300 |
| 12 | Indapamide | — | 299 |
About the Formation of the ureteric bud Pathway
The Formation of the ureteric bud pathway is catalogued in Reactome (ID: R-HSA-9830674) and involves 2 genes. In the BiohacksAI corpus, 12 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include RET, SIX1.