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BiohacksAI

Evidence-Based Biohacking

Patent Pending

Strand-asynchronous mitochondrial DNA replication

REACTOME PATHWAY
Reactome: R-HSA-99136352 genes5 compounds

The Strand-asynchronous mitochondrial DNA replication pathway (Reactome ID: R-HSA-9913635) involves 2 genes and is affected by 5 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

POLRMTRNASEH1

Compounds Affecting Strand-asynchronous mitochondrial DNA replication

#CompoundTargets HitStudies
1myricetin-3-O-galactopyranoside [Supplementary Concept]—300
2Quercetin—300
3Hematoporphyrins Iron-free derivatives of heme with 4 methyl groups, 2 hydroxyethyl groups and 2 propionic acid groups attached to—24
4juglone hydroxylase [Supplementary Concept] catalyzes—279
5Arabinofuranosylcytosine Triphosphate—22

About the Strand-asynchronous mitochondrial DNA replication Pathway

The Strand-asynchronous mitochondrial DNA replication pathway is catalogued in Reactome (ID: R-HSA-9913635) and involves 2 genes. In the BiohacksAI corpus, 5 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include POLRMT, RNASEH1.