What compounds target BTK?

BiohacksAI has identified 50 compounds that interact with BTK (Bruton tyrosine kinase). Top compounds include: osimertinib, ibrutinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is BTK (Bruton tyrosine kinase)?

BTK is Bruton tyrosine kinase. It is a molecular target for 50 compounds documented in PubMed bioassay data. UniProt ID: Q06187. NCBI Gene ID: 695.

BTK

MOLECULAR TARGET

Bruton tyrosine kinase

UniProt: Q06187 NCBI Gene: 69550 compounds

BTK (Bruton tyrosine kinase) is targeted by 50 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting BTK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	osimertinib	5.03	152
2	ibrutinib	4.86	128
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	ceritinib	4.19	65
8	bosutinib	4.08	58
9	brigatinib	3.81	44
10	neratinib	3.66	38
11	nintedanib	3.61	36
12	canertinib	3.53	33
13	pelitinib	3.50	32
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	mln 8054	3.33	27
17	saracatinib	3.33	27
18	acalabrutinib	3.22	24
19	rociletinib	3.18	23
20	sulfuretin	3.14	22
21	at 9283	3.09	21
22	lestaurtinib	3.04	20
23	spebrutinib	3.04	20
24	pf 03758309	3.00	19
25	danusertib	2.94	18
26	defosbarasertib	2.89	17
27	r 406	2.83	16
28	k 252a	2.83	16
29	cediranib	2.83	16
30	ritlecitinib	2.77	15
31	apitolisib	2.71	14
32	kw 2449	2.64	13
33	zanubrutinib	2.56	12
34	poziotinib	2.48	11
35	evobrutinib	2.48	11
36	entospletinib	2.48	11
37	azd 7762	2.30	9
38	bms 754807	2.30	9
39	olmutinib	2.30	9
40	su 014813	2.20	8
41	rebastinib	2.20	8
42	futibatinib	2.20	8
43	asp 3026	2.08	7
44	tirabrutinib	1.95	6
45	ucn 01	1.79	5
46	tolebrutinib	1.79	5
47	Crizotinib	0.69	1
48	Dasatinib	0.69	1
49	tyrphostin ag 1478	0.69	1
50	bdb pf 06651600 us11111242 example 5 us9617258 example 5	0.69	1

About BTK as a Drug Target

BTK (Bruton tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 50 compounds with documented BTK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

BTK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.