What compounds target CSF1R?

BiohacksAI has identified 65 compounds that interact with CSF1R (colony stimulating factor 1 receptor). Top compounds include: imatinib, ibrutinib, alvocidib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CSF1R (colony stimulating factor)?

CSF1R is colony stimulating factor 1 receptor. It is a molecular target for 65 compounds documented in PubMed bioassay data. NCBI Gene ID: 1436.

CSF1R

MOLECULAR TARGET

colony stimulating factor 1 receptor

NCBI Gene: 143665 compounds

CSF1R (colony stimulating factor 1 receptor) is targeted by 65 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CSF1R

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	imatinib	5.47	236
2	ibrutinib	4.86	128
3	alvocidib	4.52	91
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ponatinib	4.26	70
8	nilotinib	4.17	64
9	bosutinib	4.08	58
10	doramapimod	4.06	57
11	quizartinib	3.99	53
12	semaxanib	3.93	50
13	midostaurin	3.85	46
14	brigatinib	3.81	44
15	pazopanib	3.69	39
16	vatalanib	3.69	39
17	neratinib	3.66	38
18	nintedanib	3.61	36
19	pelitinib	3.50	32
20	tae 684	3.43	30
21	pexidartinib	3.43	30
22	fedratinib	3.40	29
23	linifanib	3.33	27
24	neflamapimod	3.30	26
25	tandutinib	3.22	24
26	dovitinib	3.09	21
27	jnj 7706621	3.09	21
28	dasatinib anhydrous	3.09	21
29	lestaurtinib	3.04	20
30	pacritinib	3.04	20
31	filgotinib	3.04	20
32	defosbarasertib	2.89	17
33	r 406	2.83	16
34	cediranib	2.83	16
35	gw632580x	2.83	16
36	masitinib	2.77	15
37	pha 665752	2.71	14
38	plx 4720	2.71	14
39	enmd 2076	2.71	14
40	kw 2449	2.64	13
41	ast 487	2.56	12
42	raf 265	2.48	11
43	motesanib	2.48	11
44	brivanib	2.48	11
45	sotuletinib	2.40	10
46	bms 754807	2.30	9
47	azd 7648	2.30	9
48	Sorafenib	2.20	8
49	su 014813	2.20	8
50	rebastinib	2.20	8

Showing top 50 of 65 compounds. Use the BiohacksAI search to explore all CSF1R modulators.

About CSF1R as a Drug Target

CSF1R (colony stimulating factor 1 receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 65 compounds with documented CSF1R interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CSF1R inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.