What compounds target DDR1?

BiohacksAI has identified 68 compounds that interact with DDR1 (discoidin domain receptor tyrosine kinase 1). Top compounds include: erlotinib, imatinib, sb 203580, cabozantinib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DDR1 (discoidin domain receptor)?

DDR1 is discoidin domain receptor tyrosine kinase 1. It is a molecular target for 68 compounds documented in PubMed bioassay data. UniProt ID: Q08345. NCBI Gene ID: 780.

DDR1

MOLECULAR TARGET

discoidin domain receptor tyrosine kinase 1

UniProt: Q08345 NCBI Gene: 78068 compounds

DDR1 (discoidin domain receptor tyrosine kinase 1) is targeted by 68 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DDR1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	imatinib	5.47	236
3	sb 203580	4.92	136
4	cabozantinib	4.39	80
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	ponatinib	4.26	70
9	nilotinib	4.17	64
10	bosutinib	4.08	58
11	doramapimod	4.06	57
12	quizartinib	3.99	53
13	midostaurin	3.85	46
14	pazopanib	3.69	39
15	vatalanib	3.69	39
16	sb 202190	3.64	37
17	nintedanib	3.61	36
18	regorafenib	3.56	34
19	canertinib	3.53	33
20	tae 684	3.43	30
21	fedratinib	3.40	29
22	bms 777607	3.37	28
23	linifanib	3.33	27
24	mln 8054	3.33	27
25	saracatinib	3.33	27
26	neflamapimod	3.30	26
27	tandutinib	3.22	24
28	dovitinib	3.09	21
29	dasatinib anhydrous	3.09	21
30	lestaurtinib	3.04	20
31	pacritinib	3.04	20
32	lenvatinib	3.04	20
33	danusertib	2.94	18
34	defosbarasertib	2.89	17
35	r 406	2.83	16
36	cediranib	2.83	16
37	milciclib	2.77	15
38	masitinib	2.77	15
39	pha 665752	2.71	14
40	plx 4720	2.71	14
41	enmd 2076	2.71	14
42	kw 2449	2.64	13
43	tivozanib	2.64	13
44	bemcentinib	2.64	13
45	ast 487	2.56	12
46	raf 265	2.48	11
47	motesanib	2.48	11
48	brivanib	2.48	11
49	mk 5108	2.48	11
50	merestinib	2.48	11

Showing top 50 of 68 compounds. Use the BiohacksAI search to explore all DDR1 modulators.

About DDR1 as a Drug Target

DDR1 (discoidin domain receptor tyrosine kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 68 compounds with documented DDR1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DDR1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.