What compounds target DDR2?

BiohacksAI has identified 57 compounds that interact with DDR2 (discoidin domain receptor tyrosine kinase 2). Top compounds include: imatinib, sb 203580, cabozantinib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is DDR2 (discoidin domain receptor)?

DDR2 is discoidin domain receptor tyrosine kinase 2. It is a molecular target for 57 compounds documented in PubMed bioassay data. UniProt ID: Q16832. NCBI Gene ID: 4921.

DDR2

MOLECULAR TARGET

discoidin domain receptor tyrosine kinase 2

UniProt: Q16832 NCBI Gene: 492157 compounds

DDR2 (discoidin domain receptor tyrosine kinase 2) is targeted by 57 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting DDR2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	imatinib	5.47	236
2	sb 203580	4.92	136
3	cabozantinib	4.39	80
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ponatinib	4.26	70
8	nilotinib	4.17	64
9	bosutinib	4.08	58
10	doramapimod	4.06	57
11	quizartinib	3.99	53
12	pazopanib	3.69	39
13	sb 202190	3.64	37
14	nintedanib	3.61	36
15	regorafenib	3.56	34
16	tae 684	3.43	30
17	fedratinib	3.40	29
18	bms 777607	3.37	28
19	linifanib	3.33	27
20	saracatinib	3.33	27
21	tandutinib	3.22	24
22	dovitinib	3.09	21
23	dasatinib anhydrous	3.09	21
24	lestaurtinib	3.04	20
25	lenvatinib	3.04	20
26	danusertib	2.94	18
27	defosbarasertib	2.89	17
28	r 406	2.83	16
29	cediranib	2.83	16
30	milciclib	2.77	15
31	masitinib	2.77	15
32	pha 665752	2.71	14
33	plx 4720	2.71	14
34	enmd 2076	2.71	14
35	kw 2449	2.64	13
36	tivozanib	2.64	13
37	ast 487	2.56	12
38	Sorafenib	2.48	11
39	raf 265	2.48	11
40	merestinib	2.48	11
41	aee 788	2.30	9
42	su 014813	2.20	8
43	rebastinib	2.20	8
44	gsk 1070916	2.20	8
45	golvatinib	2.20	8
46	amg 900	2.08	7
47	glesatinib	2.08	7
48	cep 32496	1.95	6
49	bafetinib	1.95	6
50	lucitanib	1.95	6

Showing top 50 of 57 compounds. Use the BiohacksAI search to explore all DDR2 modulators.

About DDR2 as a Drug Target

DDR2 (discoidin domain receptor tyrosine kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 57 compounds with documented DDR2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

DDR2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.