What compounds target EGFR?

BiohacksAI has identified 137 compounds that interact with EGFR (epidermal growth factor receptor). Top compounds include: tamoxifen, gefitinib, erlotinib, imatinib, osimertinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EGFR (epidermal growth factor)?

EGFR is epidermal growth factor receptor. It is a molecular target for 137 compounds documented in PubMed bioassay data. UniProt ID: P00533. NCBI Gene ID: 1956.

EGFR

MOLECULAR TARGET

epidermal growth factor receptor

UniProt: P00533 NCBI Gene: 1956137 compounds

EGFR (epidermal growth factor receptor) is targeted by 137 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EGFR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	tamoxifen	5.88	358
2	gefitinib	5.67	290
3	erlotinib	5.55	256
4	imatinib	5.47	236
5	osimertinib	5.03	152
6	sb 203580	4.92	136
7	ibrutinib	4.86	128
8	lapatinib	4.84	126
9	docetaxel	4.63	101
10	terfenadine	4.55	94
11	alvocidib	4.52	91
12	thioridazine	4.52	91
13	nelfinavir	4.51	90
14	cabozantinib	4.39	80
15	foretinib	4.34	76
16	vandetanib	4.30	73
17	caffeic acid phenethyl ester	4.25	69
18	ceritinib	4.19	65
19	shikonin	4.11	60
20	bosutinib	4.08	58
21	doramapimod	4.06	57
22	gentian violet	4.03	55
23	bi 2536	4.01	54
24	fluphenazine	3.91	49
25	zafirlukast	3.89	48
26	midostaurin	3.85	46
27	brigatinib	3.81	44
28	ciglitazone	3.81	44
29	catechol	3.76	42
30	vatalanib	3.69	39
31	neratinib	3.66	38
32	sb 202190	3.64	37
33	canertinib	3.53	33
34	pelitinib	3.50	32
35	candesartan	3.47	31
36	tae 684	3.43	30
37	fedratinib	3.40	29
38	gilteritinib	3.40	29
39	dobutamine	3.37	28
40	perhexiline	3.37	28
41	linifanib	3.33	27
42	mln 8054	3.33	27
43	saracatinib	3.33	27
44	tandutinib	3.22	24
45	acalabrutinib	3.22	24
46	rociletinib	3.18	23
47	gw305074x	3.14	22
48	pyrogallol	3.14	22
49	dacomitinib anhydrous	3.14	22
50	dovitinib	3.09	21

Showing top 50 of 137 compounds. Use the BiohacksAI search to explore all EGFR modulators.

About EGFR as a Drug Target

EGFR (epidermal growth factor receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 137 compounds with documented EGFR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EGFR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.