What compounds target EPHA1?

BiohacksAI has identified 32 compounds that interact with EPHA1 (EPH receptor A1). Top compounds include: gefitinib, alvocidib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHA1 (EPH receptor A1)?

EPHA1 is EPH receptor A1. It is a molecular target for 32 compounds documented in PubMed bioassay data. UniProt ID: P21709. NCBI Gene ID: 2041.

EPHA1

MOLECULAR TARGET

EPH receptor A1

UniProt: P21709 NCBI Gene: 204132 compounds

EPHA1 (EPH receptor A1) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHA1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	alvocidib	4.52	91
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	nintedanib	3.61	36
11	regorafenib	3.56	34
12	canertinib	3.53	33
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	mln 8054	3.33	27
16	saracatinib	3.33	27
17	dabrafenib	3.30	26
18	neflamapimod	3.30	26
19	alectinib	3.18	23
20	dasatinib anhydrous	3.09	21
21	lestaurtinib	3.04	20
22	r 406	2.83	16
23	cediranib	2.83	16
24	kw 2449	2.64	13
25	ast 487	2.56	12
26	atuveciclib	2.56	12
27	raf 265	2.48	11
28	bms 754807	2.30	9
29	rebastinib	2.20	8
30	sapitinib	1.95	6
31	Sorafenib	1.39	3
32	Crizotinib	0.69	1

About EPHA1 as a Drug Target

EPHA1 (EPH receptor A1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented EPHA1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHA1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.