What compounds target EPHA2?

BiohacksAI has identified 41 compounds that interact with EPHA2 (EPH receptor A2). Top compounds include: alvocidib, cabozantinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHA2 (EPH receptor A2)?

EPHA2 is EPH receptor A2. It is a molecular target for 41 compounds documented in PubMed bioassay data. UniProt ID: P29317. NCBI Gene ID: 1969.

EPHA2

MOLECULAR TARGET

EPH receptor A2

UniProt: P29317 NCBI Gene: 196941 compounds

EPHA2 (EPH receptor A2) is targeted by 41 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHA2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	cabozantinib	4.39	80
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	nintedanib	3.61	36
11	regorafenib	3.56	34
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	mln 8054	3.33	27
15	saracatinib	3.33	27
16	neflamapimod	3.30	26
17	alisertib	3.30	26
18	dorsomorphin	3.14	22
19	at 9283	3.09	21
20	dasatinib anhydrous	3.09	21
21	lestaurtinib	3.04	20
22	danusertib	2.94	18
23	r 406	2.83	16
24	milciclib	2.77	15
25	kw 2449	2.64	13
26	tivozanib	2.64	13
27	ast 487	2.56	12
28	raf 265	2.48	11
29	mk 5108	2.48	11
30	bms 754807	2.30	9
31	golvatinib	2.20	8
32	cyc 116	2.08	7
33	asp 3026	2.08	7
34	ly 3009120	2.08	7
35	lithoglycocholate	2.08	7
36	Sorafenib	1.95	6
37	cep 32496	1.95	6
38	bafetinib	1.95	6
39	sapitinib	1.95	6
40	Dasatinib	1.61	4
41	Crizotinib	1.10	2

About EPHA2 as a Drug Target

EPHA2 (EPH receptor A2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 41 compounds with documented EPHA2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHA2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.