What compounds target EPHA4?

BiohacksAI has identified 31 compounds that interact with EPHA4 (EPH receptor A4). Top compounds include: foretinib, tozasertib, vandetanib, ponatinib, nilotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHA4 (EPH receptor A4)?

EPHA4 is EPH receptor A4. It is a molecular target for 31 compounds documented in PubMed bioassay data. UniProt ID: P54764. NCBI Gene ID: 2043.

EPHA4

MOLECULAR TARGET

EPH receptor A4

UniProt: P54764 NCBI Gene: 204331 compounds

EPHA4 (EPH receptor A4) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHA4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	vandetanib	4.30	73
4	ponatinib	4.26	70
5	nilotinib	4.17	64
6	bosutinib	4.08	58
7	doramapimod	4.06	57
8	canertinib	3.53	33
9	tae 684	3.43	30
10	fedratinib	3.40	29
11	mln 8054	3.33	27
12	saracatinib	3.33	27
13	neflamapimod	3.30	26
14	alisertib	3.30	26
15	at 9283	3.09	21
16	dasatinib anhydrous	3.09	21
17	lestaurtinib	3.04	20
18	danusertib	2.94	18
19	r 406	2.83	16
20	milciclib	2.77	15
21	tivozanib	2.64	13
22	ast 487	2.56	12
23	raf 265	2.48	11
24	poziotinib	2.48	11
25	golvatinib	2.20	8
26	cyc 116	2.08	7
27	bafetinib	1.95	6
28	sapitinib	1.95	6
29	Sorafenib	1.79	5
30	Crizotinib	0.69	1
31	Dasatinib	0.69	1

About EPHA4 as a Drug Target

EPHA4 (EPH receptor A4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented EPHA4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHA4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.