What compounds target EPHB1?

BiohacksAI has identified 27 compounds that interact with EPHB1 (EPH receptor B1). Top compounds include: gefitinib, erlotinib, alvocidib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is EPHB1 (EPH receptor B1)?

EPHB1 is EPH receptor B1. It is a molecular target for 27 compounds documented in PubMed bioassay data. UniProt ID: P54762. NCBI Gene ID: 2047.

EPHB1

MOLECULAR TARGET

EPH receptor B1

UniProt: P54762 NCBI Gene: 204727 compounds

EPHB1 (EPH receptor B1) is targeted by 27 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting EPHB1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	alvocidib	4.52	91
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	nilotinib	4.17	64
8	bosutinib	4.08	58
9	doramapimod	4.06	57
10	nintedanib	3.61	36
11	canertinib	3.53	33
12	pelitinib	3.50	32
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	linifanib	3.33	27
16	mln 8054	3.33	27
17	neflamapimod	3.30	26
18	lestaurtinib	3.04	20
19	r 406	2.83	16
20	infigratinib	2.77	15
21	kw 2449	2.64	13
22	ast 487	2.56	12
23	atuveciclib	2.56	12
24	su 014813	2.20	8
25	Sorafenib	1.79	5
26	Crizotinib	0.69	1
27	Dasatinib	0.69	1

About EPHB1 as a Drug Target

EPHB1 (EPH receptor B1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 27 compounds with documented EPHB1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

EPHB1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.