What compounds target ERBB2?

BiohacksAI has identified 74 compounds that interact with ERBB2 (erb-b2 receptor tyrosine kinase 2). Top compounds include: paclitaxel, tamoxifen, gefitinib, erlotinib, imatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ERBB2 (erb-b2 receptor tyrosine)?

ERBB2 is erb-b2 receptor tyrosine kinase 2. It is a molecular target for 74 compounds documented in PubMed bioassay data. UniProt ID: P04626. NCBI Gene ID: 2064.

ERBB2

MOLECULAR TARGET

erb-b2 receptor tyrosine kinase 2

UniProt: P04626 NCBI Gene: 206474 compounds

ERBB2 (erb-b2 receptor tyrosine kinase 2) is targeted by 74 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ERBB2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	paclitaxel	7.17	1301
2	tamoxifen	5.88	358
3	gefitinib	5.67	290
4	erlotinib	5.55	256
5	imatinib	5.47	236
6	osimertinib	5.03	152
7	sb 203580	4.92	136
8	ibrutinib	4.86	128
9	lapatinib	4.84	126
10	alvocidib	4.52	91
11	amiodarone	4.51	90
12	foretinib	4.34	76
13	vandetanib	4.30	73
14	caffeic acid phenethyl ester	4.25	69
15	bosutinib	4.08	58
16	fluphenazine	3.91	49
17	brigatinib	3.81	44
18	neratinib	3.66	38
19	canertinib	3.53	33
20	pelitinib	3.50	32
21	candesartan	3.47	31
22	tae 684	3.43	30
23	acalabrutinib	3.22	24
24	dacomitinib anhydrous	3.14	22
25	defosbarasertib	2.89	17
26	bithionol	2.89	17
27	pu h71	2.89	17
28	benzodefchrysene	2.89	17
29	cediranib	2.83	16
30	masitinib	2.77	15
31	closantel	2.71	14
32	ebastine	2.64	13
33	zanubrutinib	2.56	12
34	cp 724714	2.56	12
35	poziotinib	2.48	11
36	tyrphostin 47	2.48	11
37	cudc 101	2.40	10
38	benzethonium chloride	2.40	10
39	tak 285	2.40	10
40	aee 788	2.30	9
41	cetylpyridinium bromide	2.20	8
42	iodoquinol	2.20	8
43	mubritinib	2.20	8
44	tg100 115	2.08	7
45	enclomiphene	2.08	7
46	canertinib dihydrochloride	2.08	7
47	lapatinib ditosylate	2.08	7
48	tyrphostin ag 879	2.08	7
49	maleimide	1.95	6
50	bastadin 7	1.95	6

Showing top 50 of 74 compounds. Use the BiohacksAI search to explore all ERBB2 modulators.

About ERBB2 as a Drug Target

ERBB2 (erb-b2 receptor tyrosine kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 74 compounds with documented ERBB2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ERBB2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.