ERN1
MOLECULAR TARGETendoplasmic reticulum to nucleus signaling 1
ERN1 (endoplasmic reticulum to nucleus signaling 1) is targeted by 23 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting ERN1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tozasertib | 4.33 | 75 |
| 2 | ruxolitinib | 4.23 | 68 |
| 3 | midostaurin | 3.85 | 46 |
| 4 | nintedanib | 3.61 | 36 |
| 5 | tae 684 | 3.43 | 30 |
| 6 | fedratinib | 3.40 | 29 |
| 7 | dabrafenib | 3.30 | 26 |
| 8 | lestaurtinib | 3.04 | 20 |
| 9 | lenvatinib | 3.04 | 20 |
| 10 | r 406 | 2.83 | 16 |
| 11 | k 252a | 2.83 | 16 |
| 12 | cediranib | 2.83 | 16 |
| 13 | bms 345541 | 2.71 | 14 |
| 14 | kw 2449 | 2.64 | 13 |
| 15 | ast 487 | 2.56 | 12 |
| 16 | su 014813 | 2.20 | 8 |
| 17 | rebastinib | 2.20 | 8 |
| 18 | asp 3026 | 2.08 | 7 |
| 19 | bdb txgkrvfsshpbaj | 2.08 | 7 |
| 20 | tanzisertib | 1.95 | 6 |
| 21 | pf 03814735 | 1.79 | 5 |
| 22 | ucn 01 | 1.79 | 5 |
| 23 | sp600125 | 0.69 | 1 |
About ERN1 as a Drug Target
ERN1 (endoplasmic reticulum to nucleus signaling 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 23 compounds with documented ERN1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
ERN1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.