What compounds target FGR?

BiohacksAI has identified 48 compounds that interact with FGR (FGR proto-oncogene, Src family tyrosine kinase). Top compounds include: gefitinib, erlotinib, imatinib, ibrutinib, foretinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FGR (FGR proto-oncogene, Src)?

FGR is FGR proto-oncogene, Src family tyrosine kinase. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: P09769. NCBI Gene ID: 2268.

FGR

MOLECULAR TARGET

FGR proto-oncogene, Src family tyrosine kinase

UniProt: P09769 NCBI Gene: 226848 compounds

FGR (FGR proto-oncogene, Src family tyrosine kinase) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FGR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	ibrutinib	4.86	128
5	foretinib	4.34	76
6	tozasertib	4.33	75
7	vandetanib	4.30	73
8	ponatinib	4.26	70
9	ceritinib	4.19	65
10	nilotinib	4.17	64
11	bosutinib	4.08	58
12	doramapimod	4.06	57
13	midostaurin	3.85	46
14	brigatinib	3.81	44
15	pazopanib	3.69	39
16	neratinib	3.66	38
17	nintedanib	3.61	36
18	canertinib	3.53	33
19	pelitinib	3.50	32
20	tae 684	3.43	30
21	fedratinib	3.40	29
22	mln 8054	3.33	27
23	saracatinib	3.33	27
24	dabrafenib	3.30	26
25	neflamapimod	3.30	26
26	dovitinib	3.09	21
27	jnj 7706621	3.09	21
28	at 9283	3.09	21
29	lestaurtinib	3.04	20
30	pf 03758309	3.00	19
31	r 406	2.83	16
32	cediranib	2.83	16
33	masitinib	2.77	15
34	pha 665752	2.71	14
35	plx 4720	2.71	14
36	apitolisib	2.71	14
37	kw 2449	2.64	13
38	ast 487	2.56	12
39	atuveciclib	2.56	12
40	zanubrutinib	2.56	12
41	motesanib	2.48	11
42	su 014813	2.20	8
43	rebastinib	2.20	8
44	Axitinib	1.10	2
45	Dasatinib	1.10	2
46	Crizotinib	0.69	1
47	Sorafenib	0.69	1
48	tyrphostin ag 1478	0.69	1

About FGR as a Drug Target

FGR (FGR proto-oncogene, Src family tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented FGR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FGR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.