What compounds target FLT1?

BiohacksAI has identified 64 compounds that interact with FLT1 (fms related receptor tyrosine kinase 1). Top compounds include: erlotinib, cabozantinib, foretinib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FLT1 (fms related receptor)?

FLT1 is fms related receptor tyrosine kinase 1. It is a molecular target for 64 compounds documented in PubMed bioassay data. UniProt ID: P17948. NCBI Gene ID: 2321.

FLT1

MOLECULAR TARGET

fms related receptor tyrosine kinase 1

UniProt: P17948 NCBI Gene: 232164 compounds

FLT1 (fms related receptor tyrosine kinase 1) is targeted by 64 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FLT1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	cabozantinib	4.39	80
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ponatinib	4.26	70
7	doramapimod	4.06	57
8	quizartinib	3.99	53
9	semaxanib	3.93	50
10	midostaurin	3.85	46
11	pazopanib	3.69	39
12	vatalanib	3.69	39
13	nintedanib	3.61	36
14	regorafenib	3.56	34
15	canertinib	3.53	33
16	bms 387032	3.47	31
17	tae 684	3.43	30
18	pexidartinib	3.43	30
19	fedratinib	3.40	29
20	linifanib	3.33	27
21	mln 8054	3.33	27
22	tandutinib	3.22	24
23	dorsomorphin	3.14	22
24	dovitinib	3.09	21
25	jnj 7706621	3.09	21
26	at 9283	3.09	21
27	lestaurtinib	3.04	20
28	lenvatinib	3.04	20
29	filgotinib	3.04	20
30	defosbarasertib	2.89	17
31	orantinib	2.89	17
32	r 406	2.83	16
33	cediranib	2.83	16
34	2378 tetrachlorodibenzo p dioxin	2.83	16
35	infigratinib	2.77	15
36	plx 4720	2.71	14
37	kw 2449	2.64	13
38	tivozanib	2.64	13
39	ast 487	2.56	12
40	Sorafenib	2.48	11
41	raf 265	2.48	11
42	defactinib	2.48	11
43	motesanib	2.48	11
44	brivanib	2.48	11
45	aee 788	2.30	9
46	su 014813	2.20	8
47	rebastinib	2.20	8
48	gsk 1070916	2.20	8
49	mk 2461	2.08	7
50	vadadustat	2.08	7

Showing top 50 of 64 compounds. Use the BiohacksAI search to explore all FLT1 modulators.

About FLT1 as a Drug Target

FLT1 (fms related receptor tyrosine kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 64 compounds with documented FLT1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FLT1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.