What compounds target FRK?

BiohacksAI has identified 61 compounds that interact with FRK (fyn related Src family tyrosine kinase). Top compounds include: gefitinib, erlotinib, imatinib, sb 203580, ibrutinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is FRK (fyn related Src)?

FRK is fyn related Src family tyrosine kinase. It is a molecular target for 61 compounds documented in PubMed bioassay data. UniProt ID: P42685. NCBI Gene ID: 2444.

FRK

MOLECULAR TARGET

fyn related Src family tyrosine kinase

UniProt: P42685 NCBI Gene: 244461 compounds

FRK (fyn related Src family tyrosine kinase) is targeted by 61 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting FRK

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	imatinib	5.47	236
4	sb 203580	4.92	136
5	ibrutinib	4.86	128
6	alvocidib	4.52	91
7	cabozantinib	4.39	80
8	foretinib	4.34	76
9	tozasertib	4.33	75
10	vandetanib	4.30	73
11	ponatinib	4.26	70
12	nilotinib	4.17	64
13	bosutinib	4.08	58
14	doramapimod	4.06	57
15	quizartinib	3.99	53
16	midostaurin	3.85	46
17	brigatinib	3.81	44
18	pazopanib	3.69	39
19	vatalanib	3.69	39
20	sb 202190	3.64	37
21	nintedanib	3.61	36
22	canertinib	3.53	33
23	pelitinib	3.50	32
24	tae 684	3.43	30
25	fedratinib	3.40	29
26	bms 777607	3.37	28
27	linifanib	3.33	27
28	saracatinib	3.33	27
29	dabrafenib	3.30	26
30	neflamapimod	3.30	26
31	dovitinib	3.09	21
32	dasatinib anhydrous	3.09	21
33	lestaurtinib	3.04	20
34	danusertib	2.94	18
35	r 406	2.83	16
36	cediranib	2.83	16
37	milciclib	2.77	15
38	masitinib	2.77	15
39	plx 4720	2.71	14
40	kw 2449	2.64	13
41	tivozanib	2.64	13
42	ast 487	2.56	12
43	zanubrutinib	2.56	12
44	raf 265	2.48	11
45	motesanib	2.48	11
46	mk 5108	2.48	11
47	lorlatinib	2.48	11
48	azd 7762	2.30	9
49	su 014813	2.20	8
50	rebastinib	2.20	8

Showing top 50 of 61 compounds. Use the BiohacksAI search to explore all FRK modulators.

About FRK as a Drug Target

FRK (fyn related Src family tyrosine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 61 compounds with documented FRK interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

FRK inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.