GRK4
MOLECULAR TARGETG protein-coupled receptor kinase 4
GRK4 (G protein-coupled receptor kinase 4) is targeted by 20 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting GRK4
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | erlotinib | 5.55 | 256 |
| 2 | tozasertib | 4.33 | 75 |
| 3 | ruxolitinib | 4.23 | 68 |
| 4 | bosutinib | 4.08 | 58 |
| 5 | midostaurin | 3.85 | 46 |
| 6 | nintedanib | 3.61 | 36 |
| 7 | tae 684 | 3.43 | 30 |
| 8 | fedratinib | 3.40 | 29 |
| 9 | dovitinib | 3.09 | 21 |
| 10 | lestaurtinib | 3.04 | 20 |
| 11 | ruboxistaurin | 2.94 | 18 |
| 12 | r 406 | 2.83 | 16 |
| 13 | pha 665752 | 2.71 | 14 |
| 14 | kw 2449 | 2.64 | 13 |
| 15 | gsk 461364 | 2.40 | 10 |
| 16 | balanol | 2.30 | 9 |
| 17 | su 014813 | 2.20 | 8 |
| 18 | tg100 115 | 2.08 | 7 |
| 19 | Axitinib | 0.69 | 1 |
| 20 | Crizotinib | 0.69 | 1 |
About GRK4 as a Drug Target
GRK4 (G protein-coupled receptor kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 20 compounds with documented GRK4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
GRK4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.