What compounds target INSR?

BiohacksAI has identified 33 compounds that interact with INSR (insulin receptor). Top compounds include: osimertinib, lapatinib, foretinib, tozasertib, ceritinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is INSR (insulin receptor)?

INSR is insulin receptor. It is a molecular target for 33 compounds documented in PubMed bioassay data. UniProt ID: P06213. NCBI Gene ID: 3643.

INSR

MOLECULAR TARGET

insulin receptor

UniProt: P06213 NCBI Gene: 364333 compounds

INSR (insulin receptor) is targeted by 33 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting INSR

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	osimertinib	5.03	152
2	lapatinib	4.84	126
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	ceritinib	4.19	65
6	brigatinib	3.81	44
7	neratinib	3.66	38
8	nintedanib	3.61	36
9	tae 684	3.43	30
10	fedratinib	3.40	29
11	entrectinib	3.18	23
12	purvalanola	3.18	23
13	lestaurtinib	3.04	20
14	r 406	2.83	16
15	infigratinib	2.77	15
16	pha 665752	2.71	14
17	kw 2449	2.64	13
18	linsitinib	2.64	13
19	ast 487	2.56	12
20	aloisine a	2.40	10
21	bms 754807	2.30	9
22	su 014813	2.20	8
23	asp 3026	2.08	7
24	purvalanol b	2.08	7
25	Crizotinib	1.95	6
26	maleimide	1.95	6
27	bastadin 7	1.95	6
28	pf 03814735	1.79	5
29	osi 632	1.79	5
30	Apigenin 5,7,4'-trihydroxy-flavone,	1.39	3
31	myricetin-3-O-galactopyranoside [Supplementary Concept]	0.69	1
32	Sorafenib	0.69	1
33	sp600125	0.69	1

About INSR as a Drug Target

INSR (insulin receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 33 compounds with documented INSR interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

INSR inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.