What compounds target LIMK1?

BiohacksAI has identified 32 compounds that interact with LIMK1 (LIM domain kinase 1). Top compounds include: ibrutinib, foretinib, tozasertib, pazopanib, regorafenib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is LIMK1 (LIM domain kinase)?

LIMK1 is LIM domain kinase 1. It is a molecular target for 32 compounds documented in PubMed bioassay data. UniProt ID: P53667. NCBI Gene ID: 3984.

LIMK1

MOLECULAR TARGET

LIM domain kinase 1

UniProt: P53667 NCBI Gene: 398432 compounds

LIMK1 (LIM domain kinase 1) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting LIMK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	ibrutinib	4.86	128
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	pazopanib	3.69	39
5	regorafenib	3.56	34
6	tae 684	3.43	30
7	fedratinib	3.40	29
8	dabrafenib	3.30	26
9	jnj 7706621	3.09	21
10	at 9283	3.09	21
11	lestaurtinib	3.04	20
12	danusertib	2.94	18
13	r 406	2.83	16
14	capivasertib	2.77	15
15	plx 4720	2.71	14
16	ast 487	2.56	12
17	damnacanthal	2.56	12
18	mk 5108	2.48	11
19	aee 788	2.30	9
20	pha 680632	2.30	9
21	rebastinib	2.20	8
22	golvatinib	2.20	8
23	encorafenib	2.20	8
24	gandotinib	2.20	8
25	cyc 116	2.08	7
26	asp 3026	2.08	7
27	Sorafenib	1.95	6
28	tanzisertib	1.95	6
29	lx 7101	1.95	6
30	Crizotinib	1.10	2
31	Dasatinib	1.10	2
32	kenpaullone	0.69	1

About LIMK1 as a Drug Target

LIMK1 (LIM domain kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented LIMK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

LIMK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.