What compounds target MAP2K2?

BiohacksAI has identified 43 compounds that interact with MAP2K2 (mitogen-activated protein kinase kinase 2). Top compounds include: sb 203580, foretinib, tozasertib, vandetanib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP2K2 (mitogen-activated protein kinase)?

MAP2K2 is mitogen-activated protein kinase kinase 2. It is a molecular target for 43 compounds documented in PubMed bioassay data. UniProt ID: P36507. NCBI Gene ID: 5605.

MAP2K2

MOLECULAR TARGET

mitogen-activated protein kinase kinase 2

UniProt: P36507 NCBI Gene: 560543 compounds

MAP2K2 (mitogen-activated protein kinase kinase 2) is targeted by 43 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP2K2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	sb 203580	4.92	136
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	ruxolitinib	4.23	68
6	bosutinib	4.08	58
7	neratinib	3.66	38
8	sb 202190	3.64	37
9	nintedanib	3.61	36
10	canertinib	3.53	33
11	pelitinib	3.50	32
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	gilteritinib	3.40	29
15	mirdametinib	3.18	23
16	trametinib	3.09	21
17	dovitinib	3.09	21
18	jnj 7706621	3.09	21
19	selumetinib	3.09	21
20	lestaurtinib	3.04	20
21	ci 1040	2.94	18
22	defosbarasertib	2.89	17
23	orantinib	2.89	17
24	r 406	2.83	16
25	k 252a	2.83	16
26	cediranib	2.83	16
27	pha 665752	2.71	14
28	plx 4720	2.71	14
29	kw 2449	2.64	13
30	linsitinib	2.64	13
31	cobimetinib	2.64	13
32	azd 7762	2.30	9
33	avutometinib	2.30	9
34	binimetinib	2.30	9
35	su 014813	2.20	8
36	amg 900	2.08	7
37	cep 32496	1.95	6
38	gsk 1059615	1.95	6
39	tak 733	1.95	6
40	pd98059	1.10	2
41	Axitinib	0.69	1
42	Dasatinib	0.69	1
43	Vemurafenib	0.69	1

About MAP2K2 as a Drug Target

MAP2K2 (mitogen-activated protein kinase kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 43 compounds with documented MAP2K2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP2K2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.