What compounds target MAP2K5?

BiohacksAI has identified 64 compounds that interact with MAP2K5 (mitogen-activated protein kinase kinase 5). Top compounds include: gefitinib, erlotinib, sb 203580, ibrutinib, lapatinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MAP2K5 (mitogen-activated protein kinase)?

MAP2K5 is mitogen-activated protein kinase kinase 5. It is a molecular target for 64 compounds documented in PubMed bioassay data. UniProt ID: Q13163. NCBI Gene ID: 5607.

MAP2K5

MOLECULAR TARGET

mitogen-activated protein kinase kinase 5

UniProt: Q13163 NCBI Gene: 560764 compounds

MAP2K5 (mitogen-activated protein kinase kinase 5) is targeted by 64 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MAP2K5

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	erlotinib	5.55	256
3	sb 203580	4.92	136
4	ibrutinib	4.86	128
5	lapatinib	4.84	126
6	alvocidib	4.52	91
7	cabozantinib	4.39	80
8	foretinib	4.34	76
9	tozasertib	4.33	75
10	vandetanib	4.30	73
11	ponatinib	4.26	70
12	nilotinib	4.17	64
13	bosutinib	4.08	58
14	pazopanib	3.69	39
15	neratinib	3.66	38
16	nintedanib	3.61	36
17	canertinib	3.53	33
18	tae 684	3.43	30
19	fedratinib	3.40	29
20	gilteritinib	3.40	29
21	bms 777607	3.37	28
22	linifanib	3.33	27
23	dabrafenib	3.30	26
24	tandutinib	3.22	24
25	mirdametinib	3.18	23
26	dovitinib	3.09	21
27	at 9283	3.09	21
28	lestaurtinib	3.04	20
29	lenvatinib	3.04	20
30	ruboxistaurin	2.94	18
31	defosbarasertib	2.89	17
32	orantinib	2.89	17
33	barasertib	2.89	17
34	r 406	2.83	16
35	k 252a	2.83	16
36	cediranib	2.83	16
37	pha 665752	2.71	14
38	plx 4720	2.71	14
39	crenolanib	2.71	14
40	apitolisib	2.71	14
41	kw 2449	2.64	13
42	linsitinib	2.64	13
43	ast 487	2.56	12
44	cp 724714	2.56	12
45	raf 265	2.48	11
46	brivanib	2.48	11
47	tak 285	2.40	10
48	azd 7762	2.30	9
49	aee 788	2.30	9
50	avutometinib	2.30	9

Showing top 50 of 64 compounds. Use the BiohacksAI search to explore all MAP2K5 modulators.

About MAP2K5 as a Drug Target

MAP2K5 (mitogen-activated protein kinase kinase 5) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 64 compounds with documented MAP2K5 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MAP2K5 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.