What compounds target MST1R?

BiohacksAI has identified 32 compounds that interact with MST1R (macrophage stimulating 1 receptor). Top compounds include: cabozantinib, foretinib, tozasertib, vandetanib, bosutinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is MST1R (macrophage stimulating 1)?

MST1R is macrophage stimulating 1 receptor. It is a molecular target for 32 compounds documented in PubMed bioassay data. NCBI Gene ID: 4486.

MST1R

MOLECULAR TARGET

macrophage stimulating 1 receptor

NCBI Gene: 448632 compounds

MST1R (macrophage stimulating 1 receptor) is targeted by 32 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting MST1R

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	cabozantinib	4.39	80
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	vandetanib	4.30	73
5	bosutinib	4.08	58
6	neratinib	3.66	38
7	tae 684	3.43	30
8	gilteritinib	3.40	29
9	bms 777607	3.37	28
10	linifanib	3.33	27
11	lestaurtinib	3.04	20
12	defosbarasertib	2.89	17
13	barasertib	2.89	17
14	r 406	2.83	16
15	cediranib	2.83	16
16	milciclib	2.77	15
17	infigratinib	2.77	15
18	pha 665752	2.71	14
19	kw 2449	2.64	13
20	ast 487	2.56	12
21	merestinib	2.48	11
22	bms 754807	2.30	9
23	rebastinib	2.20	8
24	golvatinib	2.20	8
25	Crizotinib	2.08	7
26	cyc 116	2.08	7
27	mk 2461	2.08	7
28	fostamatinib	2.08	7
29	glesatinib	2.08	7
30	pf 03814735	1.79	5
31	osi 632	1.79	5
32	alsterpaullone	0.69	1

About MST1R as a Drug Target

MST1R (macrophage stimulating 1 receptor) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 32 compounds with documented MST1R interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

MST1R inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.