NOS2
MOLECULAR TARGETnitric oxide synthase 2
NOS2 (nitric oxide synthase 2) is targeted by 21 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting NOS2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tilarginine | 4.73 | 112 |
| 2 | pimagedine | 4.53 | 92 |
| 3 | l name | 3.76 | 42 |
| 4 | l nil | 3.37 | 28 |
| 5 | chlorzoxazone | 3.30 | 26 |
| 6 | 1400w | 3.30 | 26 |
| 7 | oleanonic acid | 3.14 | 22 |
| 8 | bardoxolone | 3.00 | 19 |
| 9 | 7 nitroindazole | 2.94 | 18 |
| 10 | 2 aminopyridine | 2.83 | 16 |
| 11 | Nitroarginine | 2.48 | 11 |
| 12 | gigantol | 2.40 | 10 |
| 13 | l nio | 2.20 | 8 |
| 14 | Arginine | 1.95 | 6 |
| 15 | Arginine | 1.95 | 6 |
| 16 | gw 274150 | 1.95 | 6 |
| 17 | thiocitrulline | 1.95 | 6 |
| 18 | ethylisothiourea | 1.79 | 5 |
| 19 | NG-Nitroarginine Methyl Ester | 1.61 | 4 |
| 20 | alyssin [Supplementary Concept] | 0.69 | 1 |
| 21 | Guanethidine | 0.69 | 1 |
About NOS2 as a Drug Target
NOS2 (nitric oxide synthase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 21 compounds with documented NOS2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
NOS2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.