NOS3
MOLECULAR TARGETnitric oxide synthase 3
NOS3 (nitric oxide synthase 3) is targeted by 19 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting NOS3
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tilarginine | 4.73 | 112 |
| 2 | pimagedine | 4.53 | 92 |
| 3 | l name | 3.76 | 42 |
| 4 | l nil | 3.37 | 28 |
| 5 | chlorzoxazone | 3.30 | 26 |
| 6 | 1400w | 3.30 | 26 |
| 7 | 7 nitroindazole | 2.94 | 18 |
| 8 | 2 aminopyridine | 2.83 | 16 |
| 9 | l nio | 2.20 | 8 |
| 10 | NG-Nitroarginine Methyl Ester | 2.08 | 7 |
| 11 | gw 274150 | 1.95 | 6 |
| 12 | thiocitrulline | 1.95 | 6 |
| 13 | Nitroarginine | 1.79 | 5 |
| 14 | ethylisothiourea | 1.79 | 5 |
| 15 | Catechin | 1.10 | 2 |
| 16 | Arginine | 0.69 | 1 |
| 17 | Arginine | 0.69 | 1 |
| 18 | sesamol | 0.69 | 1 |
| 19 | bdb chembl1825168 | 0.69 | 1 |
About NOS3 as a Drug Target
NOS3 (nitric oxide synthase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 19 compounds with documented NOS3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
NOS3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.