What compounds target NTRK1?

BiohacksAI has identified 58 compounds that interact with NTRK1 (neurotrophic receptor tyrosine kinase 1). Top compounds include: cabozantinib, foretinib, tozasertib, ponatinib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is NTRK1 (neurotrophic receptor tyrosine)?

NTRK1 is neurotrophic receptor tyrosine kinase 1. It is a molecular target for 58 compounds documented in PubMed bioassay data. UniProt ID: P04629. NCBI Gene ID: 4914.

NTRK1

MOLECULAR TARGET

neurotrophic receptor tyrosine kinase 1

UniProt: P04629 NCBI Gene: 491458 compounds

NTRK1 (neurotrophic receptor tyrosine kinase 1) is targeted by 58 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting NTRK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	cabozantinib	4.39	80
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	ponatinib	4.26	70
5	ruxolitinib	4.23	68
6	ceritinib	4.19	65
7	bosutinib	4.08	58
8	doramapimod	4.06	57
9	quizartinib	3.99	53
10	midostaurin	3.85	46
11	abemaciclib	3.66	38
12	nintedanib	3.61	36
13	larotrectinib	3.50	32
14	tryptanthrin	3.47	31
15	tae 684	3.43	30
16	fedratinib	3.40	29
17	bms 777607	3.37	28
18	linifanib	3.33	27
19	tandutinib	3.22	24
20	entrectinib	3.18	23
21	gw305074x	3.14	22
22	selitrectinib	3.14	22
23	dovitinib	3.09	21
24	lestaurtinib	3.04	20
25	pf 03758309	3.00	19
26	repotrectinib	3.00	19
27	danusertib	2.94	18
28	r 406	2.83	16
29	k 252a	2.83	16
30	gw632580x	2.83	16
31	milciclib	2.77	15
32	pha 665752	2.71	14
33	crenolanib	2.71	14
34	enmd 2076	2.71	14
35	kw 2449	2.64	13
36	ast 487	2.56	12
37	defactinib	2.48	11
38	lorlatinib	2.48	11
39	merestinib	2.48	11
40	entospletinib	2.48	11
41	bms 754807	2.30	9
42	azd 1480	2.30	9
43	su 014813	2.20	8
44	rebastinib	2.20	8
45	gsk 1070916	2.20	8
46	golvatinib	2.20	8
47	mk 2461	2.08	7
48	purvalanol b	2.08	7
49	tyrphostin ag 879	2.08	7
50	sns 314 mesylate	1.95	6

Showing top 50 of 58 compounds. Use the BiohacksAI search to explore all NTRK1 modulators.

About NTRK1 as a Drug Target

NTRK1 (neurotrophic receptor tyrosine kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 58 compounds with documented NTRK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

NTRK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.