What compounds target OPRD1?

BiohacksAI has identified 35 compounds that interact with OPRD1 (opioid receptor delta 1). Top compounds include: Morphine, Naloxone, Fentanyl, Levorphanol, Nalorphine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is OPRD1 (opioid receptor delta)?

OPRD1 is opioid receptor delta 1. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: P41143. NCBI Gene ID: 4985.

OPRD1

MOLECULAR TARGET

opioid receptor delta 1

UniProt: P41143 NCBI Gene: 498535 compounds

OPRD1 (opioid receptor delta 1) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting OPRD1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Morphine	4.70	109
2	Naloxone	4.20	66
3	Fentanyl	3.14	22
4	Levorphanol	2.64	13
5	Nalorphine	2.40	10
6	Etorphine	2.20	8
7	Nalbuphine	1.95	6
8	Diprenorphine	1.79	5
9	Meperidine	1.79	5
10	Butorphanol	1.39	3
11	Dihydromorphine	1.39	3
12	Oxycodone	1.39	3
13	beta-Endorphin	1.10	2
14	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	1.10	2
15	Hydromorphone	1.10	2
16	Levallorphan	1.10	2
17	Sufentanil	1.10	2
18	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
19	cbd	0.69	1
20	Kaempferols	0.69	1
21	Alfentanil	0.69	1
22	alsterpaullone	0.69	1
23	cannabidiol	0.69	1
24	Codeine	0.69	1
25	Cyclazocine	0.69	1
26	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
27	Digoxin	0.69	1
28	Flunarizine Flunarizine is	0.69	1
29	Fluspirilene	0.69	1
30	Lanatosides Glycosides from DIGITALIS lanata leaf. Lanatoside C has actions similar to DIGOXIN. Mixtures of lanatosides A, B, and C have also been used. (From Martindale,	0.69	1
31	Metergoline	0.69	1
32	Pentazocine	0.69	1
33	Somatostatin	0.69	1
34	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	0.69	1
35	alphitonin [Supplementary Concept] from	0.69	1

About OPRD1 as a Drug Target

OPRD1 (opioid receptor delta 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented OPRD1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

OPRD1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.