What compounds target OPRK1?

BiohacksAI has identified 31 compounds that interact with OPRK1 (opioid receptor kappa 1). Top compounds include: Morphine, Naloxone, Diprenorphine, Nalbuphine, Nalorphine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is OPRK1 (opioid receptor kappa)?

OPRK1 is opioid receptor kappa 1. It is a molecular target for 31 compounds documented in PubMed bioassay data. UniProt ID: P41145. NCBI Gene ID: 4986.

OPRK1

MOLECULAR TARGET

opioid receptor kappa 1

UniProt: P41145 NCBI Gene: 498631 compounds

OPRK1 (opioid receptor kappa 1) is targeted by 31 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting OPRK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Morphine	4.32	74
2	Naloxone	4.04	56
3	Diprenorphine	3.69	39
4	Nalbuphine	2.64	13
5	Nalorphine	2.56	12
6	Levorphanol	2.48	11
7	Fentanyl	2.30	9
8	Meperidine	1.95	6
9	Butorphanol	1.79	5
10	beta-Endorphin	1.61	4
11	Etorphine	1.61	4
12	Dihydromorphine	1.39	3
13	Hydromorphone	1.39	3
14	Buprenorphine	1.10	2
15	hydrocodone	1.10	2
16	Levallorphan	1.10	2
17	Pentazocine	1.10	2
18	Sufentanil	1.10	2
19	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
20	cbd	0.69	1
21	Kaempferols	0.69	1
22	Alfentanil	0.69	1
23	cannabidiol	0.69	1
24	Codeine	0.69	1
25	Cyclazocine	0.69	1
26	Flunarizine Flunarizine is	0.69	1
27	Ibogaine	0.69	1
28	Metergoline	0.69	1
29	Oxycodone	0.69	1
30	Phenazocine	0.69	1
31	alphitonin [Supplementary Concept] from	0.69	1

About OPRK1 as a Drug Target

OPRK1 (opioid receptor kappa 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 31 compounds with documented OPRK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

OPRK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.