PDE10A
MOLECULAR TARGETphosphodiesterase 10A
PDE10A (phosphodiesterase 10A) is targeted by 9 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PDE10A
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | sildenafil | 4.78 | 118 |
| 2 | dipyridamole | 4.03 | 55 |
| 3 | zaprinast | 3.81 | 44 |
| 4 | vardenafil | 3.18 | 23 |
| 5 | mardepodect | 3.18 | 23 |
| 6 | Papaverine | 3.09 | 21 |
| 7 | pf 04217903 | 2.64 | 13 |
| 8 | papaverine hydrochloride | 2.30 | 9 |
| 9 | pf 06835919 | 1.79 | 5 |
About PDE10A as a Drug Target
PDE10A (phosphodiesterase 10A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 9 compounds with documented PDE10A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PDE10A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.