PDE5A
MOLECULAR TARGETphosphodiesterase 5A
PDE5A (phosphodiesterase 5A) is targeted by 24 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PDE5A
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | rolipram | 5.12 | 166 |
| 2 | sb 203580 | 4.92 | 136 |
| 3 | ly 294002 | 4.84 | 126 |
| 4 | sildenafil | 4.78 | 118 |
| 5 | alpha naphthoflavone | 4.67 | 106 |
| 6 | milrinone | 4.39 | 80 |
| 7 | palbociclib | 4.22 | 67 |
| 8 | dipyridamole | 4.03 | 55 |
| 9 | tadalafil | 3.93 | 50 |
| 10 | zaprinast | 3.81 | 44 |
| 11 | isobutylmethylxanthine | 3.71 | 40 |
| 12 | beta ccm | 3.26 | 25 |
| 13 | vardenafil | 3.18 | 23 |
| 14 | fpl 55712 | 3.18 | 23 |
| 15 | rutaecarpine | 3.09 | 21 |
| 16 | pptn | 2.89 | 17 |
| 17 | cilostamide | 2.56 | 12 |
| 18 | ibudilast | 2.48 | 11 |
| 19 | sophoraflavanone b | 2.48 | 11 |
| 20 | icaritin | 2.40 | 10 |
| 21 | bw a78u | 1.95 | 6 |
| 22 | Sildenafil Citrate | 1.39 | 3 |
| 23 | Epimedium | 0.69 | 1 |
| 24 | Papaverine | 0.69 | 1 |
About PDE5A as a Drug Target
PDE5A (phosphodiesterase 5A) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 24 compounds with documented PDE5A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PDE5A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.