What compounds target PDGFRA?

BiohacksAI has identified 61 compounds that interact with PDGFRA (platelet derived growth factor receptor alpha). Top compounds include: erlotinib, imatinib, alvocidib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PDGFRA (platelet derived growth)?

PDGFRA is platelet derived growth factor receptor alpha. It is a molecular target for 61 compounds documented in PubMed bioassay data. UniProt ID: P16234. NCBI Gene ID: 5156.

PDGFRA

MOLECULAR TARGET

platelet derived growth factor receptor alpha

UniProt: P16234 NCBI Gene: 515661 compounds

PDGFRA (platelet derived growth factor receptor alpha) is targeted by 61 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PDGFRA

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	imatinib	5.47	236
3	alvocidib	4.52	91
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ponatinib	4.26	70
8	ceritinib	4.19	65
9	nilotinib	4.17	64
10	bosutinib	4.08	58
11	doramapimod	4.06	57
12	quizartinib	3.99	53
13	semaxanib	3.93	50
14	midostaurin	3.85	46
15	pazopanib	3.69	39
16	vatalanib	3.69	39
17	nintedanib	3.61	36
18	regorafenib	3.56	34
19	canertinib	3.53	33
20	tae 684	3.43	30
21	pexidartinib	3.43	30
22	fedratinib	3.40	29
23	bms 777607	3.37	28
24	linifanib	3.33	27
25	mln 8054	3.33	27
26	saracatinib	3.33	27
27	neflamapimod	3.30	26
28	tandutinib	3.22	24
29	dovitinib	3.09	21
30	jnj 7706621	3.09	21
31	at 9283	3.09	21
32	lestaurtinib	3.04	20
33	lenvatinib	3.04	20
34	defosbarasertib	2.89	17
35	barasertib	2.89	17
36	r 406	2.83	16
37	cediranib	2.83	16
38	infigratinib	2.77	15
39	masitinib	2.77	15
40	pha 665752	2.71	14
41	plx 4720	2.71	14
42	crenolanib	2.71	14
43	enmd 2076	2.71	14
44	kw 2449	2.64	13
45	tivozanib	2.64	13
46	bemcentinib	2.64	13
47	ast 487	2.56	12
48	raf 265	2.48	11
49	motesanib	2.48	11
50	brivanib	2.48	11

Showing top 50 of 61 compounds. Use the BiohacksAI search to explore all PDGFRA modulators.

About PDGFRA as a Drug Target

PDGFRA (platelet derived growth factor receptor alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 61 compounds with documented PDGFRA interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PDGFRA inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.