PDK1
MOLECULAR TARGETpyruvate dehydrogenase kinase 1
PDK1 (pyruvate dehydrogenase kinase 1) is targeted by 8 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting PDK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | 6bio | 3.50 | 32 |
| 2 | at 9283 | 3.09 | 21 |
| 3 | sotrastaurin | 2.77 | 15 |
| 4 | bx 795 | 2.40 | 10 |
| 5 | benzothiazyl disulfide | 1.95 | 6 |
| 6 | ly 2090314 | 1.79 | 5 |
| 7 | chrysin | 0.69 | 1 |
| 8 | fisetin | 0.69 | 1 |
About PDK1 as a Drug Target
PDK1 (pyruvate dehydrogenase kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 8 compounds with documented PDK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
PDK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.