What compounds target PLK4?

BiohacksAI has identified 64 compounds that interact with PLK4 (polo like kinase 4). Top compounds include: erlotinib, imatinib, alvocidib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is PLK4 (polo like kinase)?

PLK4 is polo like kinase 4. It is a molecular target for 64 compounds documented in PubMed bioassay data. NCBI Gene ID: 10733.

PLK4

MOLECULAR TARGET

polo like kinase 4

NCBI Gene: 1073364 compounds

PLK4 (polo like kinase 4) is targeted by 64 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting PLK4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	imatinib	5.47	236
3	alvocidib	4.52	91
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	vandetanib	4.30	73
7	ruxolitinib	4.23	68
8	ceritinib	4.19	65
9	midostaurin	3.85	46
10	pazopanib	3.69	39
11	nintedanib	3.61	36
12	tae 684	3.43	30
13	fedratinib	3.40	29
14	gilteritinib	3.40	29
15	bms 777607	3.37	28
16	linifanib	3.33	27
17	mln 8054	3.33	27
18	dabrafenib	3.30	26
19	alisertib	3.30	26
20	tandutinib	3.22	24
21	sp 600125	3.22	24
22	jnj 7706621	3.09	21
23	at 9283	3.09	21
24	lestaurtinib	3.04	20
25	pf 03758309	3.00	19
26	ruboxistaurin	2.94	18
27	danusertib	2.94	18
28	defosbarasertib	2.89	17
29	momelotinib	2.89	17
30	go 6976	2.89	17
31	r 406	2.83	16
32	k 252a	2.83	16
33	cediranib	2.83	16
34	pha 665752	2.71	14
35	plx 4720	2.71	14
36	enmd 2076	2.71	14
37	kw 2449	2.64	13
38	mk 5108	2.48	11
39	merestinib	2.48	11
40	Axitinib	2.40	10
41	ripasudil	2.40	10
42	azd 7762	2.30	9
43	bms 754807	2.30	9
44	azd 1480	2.30	9
45	su 014813	2.20	8
46	rebastinib	2.20	8
47	gsk 1070916	2.20	8
48	decernotinib	2.20	8
49	cyc 116	2.08	7
50	asp 3026	2.08	7

Showing top 50 of 64 compounds. Use the BiohacksAI search to explore all PLK4 modulators.

About PLK4 as a Drug Target

PLK4 (polo like kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 64 compounds with documented PLK4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

PLK4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.