RAF1
MOLECULAR TARGETRaf-1 proto-oncogene, serine/threonine kinase
RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting RAF1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | imatinib | 5.47 | 236 |
| 2 | sb 203580 | 4.92 | 136 |
| 3 | foretinib | 4.34 | 76 |
| 4 | nilotinib | 4.17 | 64 |
| 5 | pi 103 | 4.17 | 64 |
| 6 | doramapimod | 4.06 | 57 |
| 7 | pazopanib | 3.69 | 39 |
| 8 | sb 202190 | 3.64 | 37 |
| 9 | regorafenib | 3.56 | 34 |
| 10 | dabrafenib | 3.30 | 26 |
| 11 | gw305074x | 3.14 | 22 |
| 12 | ci 1040 | 2.94 | 18 |
| 13 | r 406 | 2.83 | 16 |
| 14 | plx 4720 | 2.71 | 14 |
| 15 | ast 487 | 2.56 | 12 |
| 16 | raf 265 | 2.48 | 11 |
| 17 | motesanib | 2.48 | 11 |
| 18 | sb590885 | 2.40 | 10 |
| 19 | avutometinib | 2.30 | 9 |
| 20 | rebastinib | 2.20 | 8 |
| 21 | ly 3009120 | 2.08 | 7 |
| 22 | osi 930 | 2.08 | 7 |
| 23 | cep 32496 | 1.95 | 6 |
| 24 | sns 314 mesylate | 1.95 | 6 |
| 25 | naporafenib | 1.95 | 6 |
| 26 | Sorafenib | 1.10 | 2 |
| 27 | Vemurafenib | 1.10 | 2 |
| 28 | Dasatinib | 0.69 | 1 |
About RAF1 as a Drug Target
RAF1 (Raf-1 proto-oncogene, serine/threonine kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented RAF1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
RAF1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.