RIOK1
MOLECULAR TARGETRIO kinase 1
RIOK1 (RIO kinase 1) is targeted by 20 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting RIOK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tozasertib | 4.33 | 75 |
| 2 | ruxolitinib | 4.23 | 68 |
| 3 | bosutinib | 4.08 | 58 |
| 4 | bi 2536 | 4.01 | 54 |
| 5 | midostaurin | 3.85 | 46 |
| 6 | nintedanib | 3.61 | 36 |
| 7 | canertinib | 3.53 | 33 |
| 8 | fedratinib | 3.40 | 29 |
| 9 | dovitinib | 3.09 | 21 |
| 10 | jnj 7706621 | 3.09 | 21 |
| 11 | lestaurtinib | 3.04 | 20 |
| 12 | ruboxistaurin | 2.94 | 18 |
| 13 | r 406 | 2.83 | 16 |
| 14 | pha 665752 | 2.71 | 14 |
| 15 | kw 2449 | 2.64 | 13 |
| 16 | gsk 461364 | 2.40 | 10 |
| 17 | su 014813 | 2.20 | 8 |
| 18 | tg100 115 | 2.08 | 7 |
| 19 | Axitinib | 0.69 | 1 |
| 20 | Crizotinib | 0.69 | 1 |
About RIOK1 as a Drug Target
RIOK1 (RIO kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 20 compounds with documented RIOK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
RIOK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.