RIOK2
MOLECULAR TARGETRIO kinase 2
RIOK2 (RIO kinase 2) is targeted by 18 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting RIOK2
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tozasertib | 4.33 | 75 |
| 2 | ruxolitinib | 4.23 | 68 |
| 3 | pi 103 | 4.17 | 64 |
| 4 | midostaurin | 3.85 | 46 |
| 5 | pazopanib | 3.69 | 39 |
| 6 | bms 387032 | 3.47 | 31 |
| 7 | fedratinib | 3.40 | 29 |
| 8 | dovitinib | 3.09 | 21 |
| 9 | lestaurtinib | 3.04 | 20 |
| 10 | r 406 | 2.83 | 16 |
| 11 | masitinib | 2.77 | 15 |
| 12 | plx 4720 | 2.71 | 14 |
| 13 | kw 2449 | 2.64 | 13 |
| 14 | ast 487 | 2.56 | 12 |
| 15 | su 014813 | 2.20 | 8 |
| 16 | tg100 115 | 2.08 | 7 |
| 17 | elimusertib | 2.08 | 7 |
| 18 | pictilisib | 0.69 | 1 |
About RIOK2 as a Drug Target
RIOK2 (RIO kinase 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 18 compounds with documented RIOK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
RIOK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.