What compounds target STK4?

BiohacksAI has identified 38 compounds that interact with STK4 (serine/threonine kinase 4). Top compounds include: foretinib, tozasertib, bosutinib, midostaurin, molibresib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is STK4 (serine/threonine kinase 4)?

STK4 is serine/threonine kinase 4. It is a molecular target for 38 compounds documented in PubMed bioassay data. UniProt ID: Q13043. NCBI Gene ID: 6789.

STK4

MOLECULAR TARGET

serine/threonine kinase 4

UniProt: Q13043 NCBI Gene: 678938 compounds

STK4 (serine/threonine kinase 4) is targeted by 38 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting STK4

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	foretinib	4.34	76
2	tozasertib	4.33	75
3	bosutinib	4.08	58
4	midostaurin	3.85	46
5	molibresib	3.81	44
6	neratinib	3.66	38
7	nintedanib	3.61	36
8	pelitinib	3.50	32
9	tae 684	3.43	30
10	linifanib	3.33	27
11	sp 600125	3.22	24
12	dovitinib	3.09	21
13	jnj 7706621	3.09	21
14	lestaurtinib	3.04	20
15	pf 03758309	3.00	19
16	ruboxistaurin	2.94	18
17	danusertib	2.94	18
18	orantinib	2.89	17
19	k 252a	2.83	16
20	cediranib	2.83	16
21	pf 00562271	2.77	15
22	crenolanib	2.71	14
23	kw 2449	2.64	13
24	ast 487	2.56	12
25	zotiraciclib	2.56	12
26	defactinib	2.48	11
27	mk 5108	2.48	11
28	azd 7762	2.30	9
29	azd 1480	2.30	9
30	su 014813	2.20	8
31	rebastinib	2.20	8
32	cyc 116	2.08	7
33	cerdulatinib	1.95	6
34	pf 03814735	1.79	5
35	ucn 01	1.79	5
36	Axitinib	0.69	1
37	Crizotinib	0.69	1
38	sp600125	0.69	1

About STK4 as a Drug Target

STK4 (serine/threonine kinase 4) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 38 compounds with documented STK4 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

STK4 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.