What compounds target TAOK1?

BiohacksAI has identified 44 compounds that interact with TAOK1 (TAO kinase 1). Top compounds include: alvocidib, foretinib, tozasertib, ruxolitinib, nilotinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TAOK1 (TAO kinase 1)?

TAOK1 is TAO kinase 1. It is a molecular target for 44 compounds documented in PubMed bioassay data. UniProt ID: Q7L7X3. NCBI Gene ID: 57551.

TAOK1

MOLECULAR TARGET

TAO kinase 1

UniProt: Q7L7X3 NCBI Gene: 5755144 compounds

TAOK1 (TAO kinase 1) is targeted by 44 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TAOK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	foretinib	4.34	76
3	tozasertib	4.33	75
4	ruxolitinib	4.23	68
5	nilotinib	4.17	64
6	bosutinib	4.08	58
7	dinaciclib	3.87	47
8	brigatinib	3.81	44
9	silmitasertib	3.78	43
10	pazopanib	3.69	39
11	abemaciclib	3.66	38
12	bms 387032	3.47	31
13	tae 684	3.43	30
14	fedratinib	3.40	29
15	linifanib	3.33	27
16	at 7519	3.33	27
17	at 9283	3.09	21
18	lestaurtinib	3.04	20
19	pacritinib	3.04	20
20	ruboxistaurin	2.94	18
21	r 406	2.83	16
22	k 252a	2.83	16
23	milciclib	2.77	15
24	pha 665752	2.71	14
25	crenolanib	2.71	14
26	kw 2449	2.64	13
27	gsk 690693	2.64	13
28	ast 487	2.56	12
29	zotiraciclib	2.56	12
30	ulixertinib	2.56	12
31	raf 265	2.48	11
32	defactinib	2.48	11
33	su 014813	2.20	8
34	decernotinib	2.20	8
35	y 39983	2.20	8
36	tg100 115	2.08	7
37	rg 547	2.08	7
38	amg 900	2.08	7
39	ravoxertinib	2.08	7
40	gsk 1059615	1.95	6
41	Sorafenib	1.39	3
42	Crizotinib	0.69	1
43	Dasatinib	0.69	1
44	sp600125	0.69	1

About TAOK1 as a Drug Target

TAOK1 (TAO kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 44 compounds with documented TAOK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TAOK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.