What compounds target TAOK3?

BiohacksAI has identified 43 compounds that interact with TAOK3 (TAO kinase 3). Top compounds include: alvocidib, tozasertib, ponatinib, ruxolitinib, palbociclib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TAOK3 (TAO kinase 3)?

TAOK3 is TAO kinase 3. It is a molecular target for 43 compounds documented in PubMed bioassay data. UniProt ID: Q9H2K8. NCBI Gene ID: 51347.

TAOK3

MOLECULAR TARGET

TAO kinase 3

UniProt: Q9H2K8 NCBI Gene: 5134743 compounds

TAOK3 (TAO kinase 3) is targeted by 43 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TAOK3

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	alvocidib	4.52	91
2	tozasertib	4.33	75
3	ponatinib	4.26	70
4	ruxolitinib	4.23	68
5	palbociclib	4.22	67
6	nilotinib	4.17	64
7	bosutinib	4.08	58
8	bi 2536	4.01	54
9	dinaciclib	3.87	47
10	pazopanib	3.69	39
11	neratinib	3.66	38
12	abemaciclib	3.66	38
13	bms 387032	3.47	31
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	linifanib	3.33	27
17	at 7519	3.33	27
18	lestaurtinib	3.04	20
19	ruboxistaurin	2.94	18
20	r 406	2.83	16
21	cediranib	2.83	16
22	milciclib	2.77	15
23	pf 00562271	2.77	15
24	pha 665752	2.71	14
25	kw 2449	2.64	13
26	gsk 690693	2.64	13
27	ast 487	2.56	12
28	zotiraciclib	2.56	12
29	raf 265	2.48	11
30	defactinib	2.48	11
31	gsk 461364	2.40	10
32	ripasudil	2.40	10
33	su 014813	2.20	8
34	rebastinib	2.20	8
35	decernotinib	2.20	8
36	encorafenib	2.20	8
37	tg100 115	2.08	7
38	rg 547	2.08	7
39	amg 900	2.08	7
40	pf 03814735	1.79	5
41	ucn 01	1.79	5
42	Sorafenib	1.10	2
43	Crizotinib	0.69	1

About TAOK3 as a Drug Target

TAOK3 (TAO kinase 3) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 43 compounds with documented TAOK3 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TAOK3 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.