What compounds target TBK1?

BiohacksAI has identified 35 compounds that interact with TBK1 (TANK binding kinase 1). Top compounds include: erlotinib, alvocidib, foretinib, tozasertib, ruxolitinib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TBK1 (TANK binding kinase)?

TBK1 is TANK binding kinase 1. It is a molecular target for 35 compounds documented in PubMed bioassay data. UniProt ID: Q9UHD2. NCBI Gene ID: 29110.

TBK1

MOLECULAR TARGET

TANK binding kinase 1

UniProt: Q9UHD2 NCBI Gene: 2911035 compounds

TBK1 (TANK binding kinase 1) is targeted by 35 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TBK1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	erlotinib	5.55	256
2	alvocidib	4.52	91
3	foretinib	4.34	76
4	tozasertib	4.33	75
5	ruxolitinib	4.23	68
6	bosutinib	4.08	58
7	midostaurin	3.85	46
8	silmitasertib	3.78	43
9	nintedanib	3.61	36
10	tae 684	3.43	30
11	fedratinib	3.40	29
12	dovitinib	3.09	21
13	at 9283	3.09	21
14	lestaurtinib	3.04	20
15	pacritinib	3.04	20
16	filgotinib	3.04	20
17	adavosertib	3.04	20
18	pf 03758309	3.00	19
19	ruboxistaurin	2.94	18
20	momelotinib	2.89	17
21	orantinib	2.89	17
22	r 406	2.83	16
23	k 252a	2.83	16
24	milciclib	2.77	15
25	pha 665752	2.71	14
26	kw 2449	2.64	13
27	bx 795	2.40	10
28	su 014813	2.20	8
29	cyc 116	2.08	7
30	cerdulatinib	1.95	6
31	pf 03814735	1.79	5
32	ucn 01	1.79	5
33	amlexanox	1.61	4
34	Axitinib	0.69	1
35	Crizotinib	0.69	1

About TBK1 as a Drug Target

TBK1 (TANK binding kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 35 compounds with documented TBK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TBK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.