What compounds target TNK2?

BiohacksAI has identified 40 compounds that interact with TNK2 (tyrosine kinase non receptor 2). Top compounds include: gefitinib, osimertinib, tofacitinib, foretinib, tozasertib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is TNK2 (tyrosine kinase non)?

TNK2 is tyrosine kinase non receptor 2. It is a molecular target for 40 compounds documented in PubMed bioassay data. UniProt ID: Q07912. NCBI Gene ID: 10188.

TNK2

MOLECULAR TARGET

tyrosine kinase non receptor 2

UniProt: Q07912 NCBI Gene: 1018840 compounds

TNK2 (tyrosine kinase non receptor 2) is targeted by 40 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting TNK2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	gefitinib	5.67	290
2	osimertinib	5.03	152
3	tofacitinib	4.65	104
4	foretinib	4.34	76
5	tozasertib	4.33	75
6	ruxolitinib	4.23	68
7	ceritinib	4.19	65
8	bosutinib	4.08	58
9	midostaurin	3.85	46
10	neratinib	3.66	38
11	nintedanib	3.61	36
12	pelitinib	3.50	32
13	larotrectinib	3.50	32
14	tae 684	3.43	30
15	fedratinib	3.40	29
16	gilteritinib	3.40	29
17	saracatinib	3.33	27
18	entrectinib	3.18	23
19	upadacitinib	3.09	21
20	lestaurtinib	3.04	20
21	pacritinib	3.04	20
22	danusertib	2.94	18
23	r 406	2.83	16
24	k 252a	2.83	16
25	milciclib	2.77	15
26	plx 4720	2.71	14
27	kw 2449	2.64	13
28	mk 5108	2.48	11
29	lorlatinib	2.48	11
30	azd 7762	2.30	9
31	aee 788	2.30	9
32	azd 1480	2.30	9
33	su 014813	2.20	8
34	asp 3026	2.08	7
35	pf 03814735	1.79	5
36	ucn 01	1.79	5
37	Dasatinib	1.10	2
38	Vemurafenib	1.10	2
39	Axitinib	0.69	1
40	Crizotinib	0.69	1

About TNK2 as a Drug Target

TNK2 (tyrosine kinase non receptor 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 40 compounds with documented TNK2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

TNK2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.