ULK1
MOLECULAR TARGETunc-51 like autophagy activating kinase 1
ULK1 (unc-51 like autophagy activating kinase 1) is targeted by 25 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting ULK1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | ruxolitinib | 4.23 | 68 |
| 2 | bosutinib | 4.08 | 58 |
| 3 | silmitasertib | 3.78 | 43 |
| 4 | nintedanib | 3.61 | 36 |
| 5 | baricitinib | 3.56 | 34 |
| 6 | bms 387032 | 3.47 | 31 |
| 7 | tae 684 | 3.43 | 30 |
| 8 | fedratinib | 3.40 | 29 |
| 9 | dabrafenib | 3.30 | 26 |
| 10 | dovitinib | 3.09 | 21 |
| 11 | lestaurtinib | 3.04 | 20 |
| 12 | r 406 | 2.83 | 16 |
| 13 | milciclib | 2.77 | 15 |
| 14 | pha 665752 | 2.71 | 14 |
| 15 | crenolanib | 2.71 | 14 |
| 16 | kw 2449 | 2.64 | 13 |
| 17 | gsk 690693 | 2.64 | 13 |
| 18 | ast 487 | 2.56 | 12 |
| 19 | hydroxyfasudil | 2.40 | 10 |
| 20 | bx 795 | 2.40 | 10 |
| 21 | azd 7762 | 2.30 | 9 |
| 22 | su 014813 | 2.20 | 8 |
| 23 | amg 900 | 2.08 | 7 |
| 24 | pf 03814735 | 1.79 | 5 |
| 25 | Crizotinib | 0.69 | 1 |
About ULK1 as a Drug Target
ULK1 (unc-51 like autophagy activating kinase 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 25 compounds with documented ULK1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
ULK1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.