WEE1
MOLECULAR TARGETWEE1 G2 checkpoint kinase
WEE1 (WEE1 G2 checkpoint kinase) is targeted by 28 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting WEE1
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | tozasertib | 4.33 | 75 |
| 2 | bosutinib | 4.08 | 58 |
| 3 | midostaurin | 3.85 | 46 |
| 4 | neratinib | 3.66 | 38 |
| 5 | nintedanib | 3.61 | 36 |
| 6 | pelitinib | 3.50 | 32 |
| 7 | tae 684 | 3.43 | 30 |
| 8 | fedratinib | 3.40 | 29 |
| 9 | dovitinib | 3.09 | 21 |
| 10 | lestaurtinib | 3.04 | 20 |
| 11 | adavosertib | 3.04 | 20 |
| 12 | pf 03758309 | 3.00 | 19 |
| 13 | volasertib | 2.94 | 18 |
| 14 | r 406 | 2.83 | 16 |
| 15 | pd 0166285 | 2.83 | 16 |
| 16 | milciclib | 2.77 | 15 |
| 17 | kw 2449 | 2.64 | 13 |
| 18 | defactinib | 2.48 | 11 |
| 19 | aee 788 | 2.30 | 9 |
| 20 | su 014813 | 2.20 | 8 |
| 21 | cyc 116 | 2.08 | 7 |
| 22 | pf 03814735 | 1.79 | 5 |
| 23 | ucn 01 | 1.79 | 5 |
| 24 | Fluocinonide | 0.69 | 1 |
| 25 | indirubin | 0.69 | 1 |
| 26 | Pemoline | 0.69 | 1 |
| 27 | Sulfaguanidine | 0.69 | 1 |
| 28 | Ursodeoxycholic Acid | 0.69 | 1 |
About WEE1 as a Drug Target
WEE1 (WEE1 G2 checkpoint kinase) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 28 compounds with documented WEE1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
WEE1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.