ZAP70
MOLECULAR TARGETzeta chain of T cell receptor associated protein kinase 70
ZAP70 (zeta chain of T cell receptor associated protein kinase 70) is targeted by 15 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).
Compounds Targeting ZAP70
Ranked by bioassay confidence score (PubChem active assay count × evidence quality).
| # | Compound | Confidence | Active Assays |
|---|---|---|---|
| 1 | ceritinib | 4.19 | 65 |
| 2 | bosutinib | 4.08 | 58 |
| 3 | quizartinib | 3.99 | 53 |
| 4 | semaxanib | 3.93 | 50 |
| 5 | midostaurin | 3.85 | 46 |
| 6 | nintedanib | 3.61 | 36 |
| 7 | tae 684 | 3.43 | 30 |
| 8 | fedratinib | 3.40 | 29 |
| 9 | lestaurtinib | 3.04 | 20 |
| 10 | defosbarasertib | 2.89 | 17 |
| 11 | orantinib | 2.89 | 17 |
| 12 | r 406 | 2.83 | 16 |
| 13 | kw 2449 | 2.64 | 13 |
| 14 | Crizotinib | 0.69 | 1 |
| 15 | Swainsonine | 0.69 | 1 |
About ZAP70 as a Drug Target
ZAP70 (zeta chain of T cell receptor associated protein kinase 70) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 15 compounds with documented ZAP70 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.
ZAP70 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.