BiohacksAI/Mechanism Hypothesis/Alprostadil

Alprostadil — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9CYTOCHROMENSD2HISTONE-LYSINEHOMODRD1RGS4RAPGEF4PTGER2ABCC4SLCO2B1MRGPRX1PTGER3NR4A2SLCO2A1PTGER1PTGER4PTGDRPTGIRCATIONCATSPER1CATSPER2CATSPER4SLCO3A1

27 known targets mapped from PubChem bioassay data

Pathway Context

Class A/1 (Rhodopsin-like receptors)6 targets overlapping

Drug ADME5 targets overlapping

G alpha (s) signalling events5 targets overlapping

Uncovered Pathway Targets

214 total

ADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2+204 more…

Genes present in the top pathway union that Alprostadil does not directly modulate.

Top Stack Candidates

Aripiprazole

#1 gap-filler · 33 targets covered · evidence score 52.0

score 6,766.078

ADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1AVPR1A+21

Fluoxetine

#2 gap-filler · 23 targets covered · evidence score 73.4

score 6,754.758

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD2EDNRA+11

850 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.