BiohacksAI/Mechanism Hypothesis/Aprepitant

Aprepitant — Mechanism Gap Analysis

HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal

Known Targets

CYP2C19CYP2D6ARCYP2C9ESR1CYTOCHROMETDP1THRBESRRACYP3A4CYP3A7GLI3RATTUSNSD2RORCHISTONE-LYSINENUCLEARTP53KCNH2RARAHOMOCYP19A1CASP3PPARDCASP7RXFP1GPR35TACR1TACR3GPR183GPR65

31 known targets mapped from PubChem bioassay data

Pathway Context

Biological oxidations6 targets overlapping

Phase I - Functionalization of compounds6 targets overlapping

Cytochrome P450 - arranged by substrate type6 targets overlapping

Uncovered Pathway Targets

191 total

AADACAHCYAHRALDH1A1ALDH2AOC1ARNTCBR3CES1CES2+181 more…

Genes present in the top pathway union that Aprepitant does not directly modulate.

Top Stack Candidates

Aripiprazole

#1 gap-filler · 32 targets covered · evidence score 52.0

score 6,510.261

MAOAADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1+20

Fluoxetine

#2 gap-filler · 22 targets covered · evidence score 73.4

score 6,483.458

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1DRD1DRD2+10

820 more candidates · full stack optimisation locked

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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.