Clotrimazole — Mechanism Gap Analysis
HYPOTHESIS_ENGINE_v1.0 · Corpus v20260227-01 · Deterministic graph-traversal
Known Targets
CYP2C19CYP2D6ARCYP2C9NR1I2ESR1CYTOCHROMETDP1CYP1A2THRBESRRACYP3A4CYP3A7NFE2L2SYKTYROSINE-PROTEINCHAINGLI3PGRNSD2RORCMUSHISTONE-LYSINENUCLEARTP53NR3C1ABCB1KCNH2RARACHRM15-HYDROXYTRYPTAMINEHOMOHTR2ADRD2ESR2DRD1CYP19A1AHRIFNGPPARGADRB2TSHRJUNATXN2SLC6A4NR1H4MU-TYPEKAPPA-TYPEGMNNSODIUM-DEPENDENTANDROGENALPHA-2AABCB11HIF1AADORA3GLUCOCORTICOIDALPHA-2BPPARDALPHA-1DHSPB1BAZ2BMUSCARINICADRB3HSP90AA1RAPGEF4GPR151CBX1HISTAMINECACNA1CTHPOADENOSINEMAPK1NPSR1TRHRKCNQ1RXFP1BETA-1THYROIDCDK1GLP1RDELTA-TYPEBETA-3PPP1CAKCNQ2DDIT3TRPM2NR1I3ABHD17BKCNK3SUBSTANCE-KAVPR2CYP2C8THROMBOXANE-ATRPM4GPR55VCPABCB1ACFL1TRPM8POTASSIUMCYP17A1ABCB1BSLC12A5SUBSTANCE-PCYP51IDO2KCNA3CYP51A1CYP8B1KCNN4CCR4CXCR1CYTH2EPHX1
114 known targets mapped from PubChem bioassay data
Pathway Context
Class A/1 (Rhodopsin-like receptors)15 targets overlapping
Biological oxidations12 targets overlapping
Phase I - Functionalization of compounds12 targets overlapping
Uncovered Pathway Targets
205 totalADORA2BADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1AGTR1AGTR2+195 more…
Genes present in the top pathway union that Clotrimazole does not directly modulate.
Top Stack Candidates
Fluoxetine
score 5,818.536#1 gap-filler · 19 targets covered · evidence score 73.4
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CCCKBRCHRM3CHRM5CNR1EDNRAHRH1+7
Aripiprazole
score 5,546.093#2 gap-filler · 26 targets covered · evidence score 52.0
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1AGTR1AVPR1ACHRM2DRD3DRD4+14
695 more candidates · full stack optimisation locked
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BiohacksAI maps biological mechanisms. It does not recommend compounds. Results generated by HYPOTHESIS_ENGINE_v1.0.