Downregulation of ERBB4 signaling
REACTOME PATHWAYThe Downregulation of ERBB4 signaling pathway (Reactome ID: R-HSA-1253288) involves 2 genes and is affected by 13 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.
Genes in this Pathway
Compounds Affecting Downregulation of ERBB4 signaling
| # | Compound | Targets Hit | Studies |
|---|---|---|---|
| 1 | Dasatinib | — | 299 |
| 2 | tyrphostin ag 1478 | — | 4 |
| 3 | Afatinib | — | 297 |
| 4 | Resveratrol | — | 298 |
| 5 | Sorafenib | — | 300 |
| 6 | Quercetin | — | 300 |
| 7 | Adenosine Monophosphate Adenine nucleotide containing | — | 300 |
| 8 | alsterpaullone | — | 12 |
| 9 | Crizotinib | — | 298 |
| 10 | kenpaullone | — | 8 |
| 11 | monorden | — | 8 |
| 12 | Niclosamide | — | 299 |
| 13 | sp600125 | — | 117 |
About the Downregulation of ERBB4 signaling Pathway
The Downregulation of ERBB4 signaling pathway is catalogued in Reactome (ID: R-HSA-1253288) and involves 2 genes. In the BiohacksAI corpus, 13 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ERBB4, SRC.